| First Author | Radulovic K | Year | 2019 |
| Journal | J Immunol | Volume | 203 |
| Issue | 2 | Pages | 544-556 |
| PubMed ID | 31152078 | Mgi Jnum | J:283447 |
| Mgi Id | MGI:6323848 | Doi | 10.4049/jimmunol.1800938 |
| Citation | Radulovic K, et al. (2019) NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death. J Immunol 203(2):544-556 |
| abstractText | The nucleotide-binding oligomerization domain (NOD)-like receptors belong to the family of pattern recognition receptors (PRRs). NOD-like receptors play a role in regulation of innate immune response by recognition of both pathogen-associated molecular patterns that are engulfed during phagocytic process and danger-associated molecular patterns that are mainly byproducts of cell stress mediated response. NOD-like family pyrin domain containing 6 (NLRP6) is one of the 14 pyrin domain-containing receptors. NLRP6 is highly expressed by epithelial and goblet cells to regulate epithelial renewal and mucus production in mice and humans, but its function in T cells is rather unknown. Increased caspase-1 activation and cell death were observed in mouse Nlrp6-deficient T cells following adoptive transfer into Rag2-deficient mice, indicating that Nlrp6 deficiency in CD4(+) T cells led to decreased survival. |
