| First Author | Zhu X | Year | 2024 |
| Journal | Sci Adv | Volume | 10 |
| Issue | 13 | Pages | eadk0858 |
| PubMed ID | 38552009 | Mgi Jnum | J:348969 |
| Mgi Id | MGI:7617901 | Doi | 10.1126/sciadv.adk0858 |
| Citation | Zhu X, et al. (2024) Antiviral memory B cells exhibit enhanced innate immune response facilitated by epigenetic memory. Sci Adv 10(13):eadk0858 |
| abstractText | The long-lasting humoral immunity induced by viral infections or vaccinations depends on memory B cells with greatly increased affinity to viral antigens, which are evolved from germinal center (GC) responses. However, it is unclear whether antiviral memory B cells represent a distinct subset among the highly heterogeneous memory B cell population. Here, we examined memory B cells induced by a virus-mimicking antigen at both transcriptome and epigenetic levels and found unexpectedly that antiviral memory B cells exhibit an enhanced innate immune response, which appeared to be facilitated by the epigenetic memory that is established through the memory B cell development. In addition, T-bet is associated with the altered chromatin architecture and is required for the formation of the antiviral memory B cells. Thus, antiviral memory B cells are distinct from other GC-derived memory B cells in both physiological functions and epigenetic landmarks. |
