| First Author | Heckman KL | Year | 2008 |
| Journal | Eur J Immunol | Volume | 38 |
| Issue | 9 | Pages | 2464-74 |
| PubMed ID | 18819071 | Mgi Jnum | J:140098 |
| Mgi Id | MGI:3811938 | Doi | 10.1002/eji.200737952 |
| Citation | Heckman KL, et al. (2008) T-bet expression by dendritic cells is required for the repolarization of allergic airway inflammation. Eur J Immunol 38(9):2464-74 |
| abstractText | By cross-linking B7-DC on dendritic cells (DC) the human IgM antibody (B7-DC XAb) shifts polarized immune responses from Th2 to Th1 in an antigen-specific manner. The molecular determinants governing the ability of DC to reprogram the polarity of T cell recall responses are not yet known. In addition to the expected role of T-bet expressed by T cells in regulating Th1 responses, we find using in vitro assays and an established in vivo model of allergic airway inflammation that T-bet expression by DC is also required for the polarity shift promoted by B7-DC XAb. T-bet expression by both T cells and DC is critically important for B7-DC XAb-induced down-regulation of IL-4, up-regulation of IFN-gamma and suppression of allergic airway inflammation. Moreover, retroviral reconstitution of T-bet expression in T-bet-deficient DC rescued their ability to modulate both naive and memory T-cell responses from Th2 to Th1. Our observations further our understanding of the critical mediators controlling the ability of DC to modify the responses of previously activated T cells and reveal the interesting use of the same transcription factor to regulate the inductive phenotype of DC and the inducible phenotype of T cells. |
