| First Author | Yang Q | Year | 2011 |
| Journal | Eur J Immunol | Volume | 41 |
| Issue | 11 | Pages | 3351-60 |
| PubMed ID | 21887788 | Mgi Jnum | J:179516 |
| Mgi Id | MGI:5302598 | Doi | 10.1002/eji.201141629 |
| Citation | Yang Q, et al. (2011) IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells. Eur J Immunol 41(11):3351-60 |
| abstractText | The effector functions of CD8(+) T cells are influenced by tissue inflammatory microenvironments. IL-33, a member of the IL-1 family, acts as a danger signal after its release during cell necrosis. The IL-33/ST2 axis has been implicated in various Th2 responses. Its role in CD8(+) T-cell-mediated immune response is, however, not known. Here we find that type 1 cytotoxic T (Tc1) cells cultured in vitro unexpectedly express high levels of the IL-33 receptor ST2. Interestingly, the expression of ST2 in Tc1 cells is dependent on T-bet, a master Th1/Tc1 transcription factor. In addition, IL-33 enhances TCR-triggered IFN-gamma production. IL-33 together with IL-12 can stimulate IFN-gamma production in Tc1 cells. Moreover, IL-33 synergizes with IL-12 to promote CD8(+) T-cell effector function. The synergistic effect of IL-33 and IL-12 is partly mediated by Gadd45b. Together, these in vitro data establish a novel role of IL-33 in promoting effector type 1 adaptive immune responses. |
