| First Author | Peng SL | Year | 2004 |
| Journal | Cancer Res | Volume | 64 |
| Issue | 2 | Pages | 452-5 |
| PubMed ID | 14744755 | Mgi Jnum | J:88093 |
| Mgi Id | MGI:3029113 | Doi | 10.1158/0008-5472.can-03-3401 |
| Citation | Peng SL, et al. (2004) T-bet regulates metastasis rate in a murine model of primary prostate cancer. Cancer Res 64(2):452-5 |
| abstractText | The local progression of primary tumors is extrinsically controlled by type 1 immune responses, particularly via the cytokine IFN-gamma, whose secretion is highly dependent on helper T cells. The T-box transcription factor T-bet (Tbx21) plays a critical role in the development of type 1 helper T cells and is essential for the production of IFN-gamma. Here, the T-bet pathway in the autochthonous transgenic adenocarcinoma mouse prostate model is demonstrated to have only a modest effect on the characteristics of primary prostate cancers but rather exerts a significant suppressor function in the development of metastatic disease. |
