| First Author | Makino Y | Year | 2002 |
| Journal | Clin Immunol | Volume | 102 |
| Issue | 3 | Pages | 302-9 |
| PubMed ID | 11890717 | Mgi Jnum | J:75842 |
| Mgi Id | MGI:2177917 | Doi | 10.1006/clim.2001.5178 |
| Citation | Makino Y, et al. (2002) Impaired T cell function in RANTES-deficient mice. Clin Immunol 102(3):302-9 |
| abstractText | The chemokine RANTES is a chemoattractant for monocytes and T cells and is postulated to participate in many aspects of the immune response. To evaluate the biological roles of RANTES in vivo, we generated RANTES-deficient (-/-) mice and characterized their T cell function. In cutaneous delayed-type hypersensitivity assays, a 50% reduction in ear and footpad swelling was seen in -/- mice compared to +/+ mice. In vitro, polyclonal and antigen-specific T cell proliferation was decreased. Quantitative analysis using the fluorescent dye carboxy-fluorescein succinimidyl ester revealed that this proliferative defect was due both to fewer antigen-reactive T cells and to a reduction in the capacity of these cells to proliferate. In addition, IFN-gamma and IL-2 production by the -/- T cells was dramatically decreased. Together, these data suggest that RANTES is required for normal T cell functions as well as for recruiting monocytes and T cells to sites of inflammation. |
