| First Author | Speirs K | Year | 2002 |
| Journal | J Immunol | Volume | 168 |
| Issue | 9 | Pages | 4406-13 |
| PubMed ID | 11970983 | Mgi Jnum | J:76158 |
| Mgi Id | MGI:2178724 | Doi | 10.4049/jimmunol.168.9.4406 |
| Citation | Speirs K, et al. (2002) NF-kappaB2 Is Required for Optimal CD40-Induced IL-12 Production but Dispensable for Th1 Cell Differentiation. J Immunol 168(9):4406-13 |
| abstractText | NF-kappaB is a ubiquitously expressed transcription factor involved in the regulation of innate and adaptive immunity. As part of studies to define the role of various NF-kappaB family members in Th cell development and maintenance, we infected NF-kappaB2(-/-) and control mice with Leishmania major and followed disease progression. NF-kappaB2(-/-) mice on a normally resistant background develop chronic nonhealing lesions associated with uncontrolled parasite replication and a failure to develop an IFN-gamma response. We show that there are no intrinsic defects in Th cell differentiation in the absence of NF-kappaB2. Indeed, NF-kappaB2(-/-) T cells are able to develop a Th1 phenotype and protect recombination-activating gene(-/-) mice from progressive cutaneous leishmaniasis. We demonstrate instead that the susceptibility of NF-kappaB2(-/-) mice to L. major is the result of an IL-12 deficiency, and we provide evidence for a specific impairment in CD40-induced IL-12 production by macrophages lacking this transcription factor. |
