| First Author | Furukawa T | Year | 1999 |
| Journal | Nat Genet | Volume | 23 |
| Issue | 4 | Pages | 466-70 |
| PubMed ID | 10581037 | Mgi Jnum | J:58796 |
| Mgi Id | MGI:1350444 | Doi | 10.1038/70591 |
| Citation | Furukawa T, et al. (1999) Retinopathy and attenuated circadian entrainment in Crx-deficient mice. Nat Genet 23(4):466-70 |
| abstractText | Crx, an Otx-like homeobox gene, is expressed specifically in the photoreceptors of the retina and the pinealocytes of the pineal gland. Crx has been proposed to have a role in the regulation of photoreceptor-specific genes in the eye and of pineal-specific genes in the pineal gland. Mutations in human CRX are associated with the retinal diseases, cone-rod dystrophy-2 (adCRD2; refs 3, 4, 5), retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA), which all lead to loss of vision. We generated mice carrying a targeted disruption of Crx. Crx-/- mice do not elaborate photoreceptor outer segments and lacked rod and cone activity as assayed by electroretinogram (ERG). Expression of several photoreceptor- and pineal-specific genes was reduced in Crx mutants. Circadian entrainment was also affected in Crx-/- mice. |
