| First Author | Cavelier P | Year | 2002 |
| Journal | Neurosci Lett | Volume | 333 |
| Issue | 1 | Pages | 64-8 |
| PubMed ID | 12401561 | Mgi Jnum | J:107960 |
| Mgi Id | MGI:3622595 | Doi | 10.1016/s0304-3940(02)00962-x |
| Citation | Cavelier P, et al. (2002) Cerebellar slice cultures from mice lacking the P/Q calcium channel: electroresponsiveness of Purkinje cells. Neurosci Lett 333(1):64-8 |
| abstractText | To investigate the role of P/Q type Ca(2+) channels in determining the firing pattern of Purkinje cells (PCs) we compared the somatically evoked discharge of action potentials (APs) in PCs from 3 to 4 week old cerebellar slice cultures obtained with ataxic mice lacking alpha(1A)-subunit (alpha(-/-)) and with normal mice (non-ataxic alpha(+/-) or alpha(+/+)) using the whole-cell configuration of the patch-clamp recording method. Whereas evoked responses of PCs in normal mice were mainly fast APs, those of PCs from ataxic mice were mainly low-threshold Ca(2+) spikes (LTS). Furthermore, a sustained plateau potential due to the activation of cadmium sensitive Ca(2+) conductances was not observed in PCs from ataxic mice by blocking K(+) channels. These results confirm that P/Q Ca(2+) channels elicit Ca(2+)-dependent plateau potentials and control the propagation of the dendritic LTS to the soma. |
