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Publication : Circulating gastrin is increased in hemochromatosis.

First Author  Smith KA Year  2006
Journal  FEBS Lett Volume  580
Issue  26 Pages  6195-8
PubMed ID  17064691 Mgi Jnum  J:117706
Mgi Id  MGI:3697278 Doi  10.1016/j.febslet.2006.10.021
Citation  Smith KA, et al. (2006) Circulating gastrin is increased in hemochromatosis. FEBS Lett 580(26):6195-8
abstractText  Gastric acid production is important in intestinal iron absorption. The peptide hormone gastrin exists in both amidated and non-amidated forms, which stimulate and potentiate gastric acid secretion, respectively. Since non-amidated gastrins require ferric ions for biological activity in vitro, this study investigated the connection between iron status and gastrin by measurement of circulating gastrin concentrations in mice and humans with hemochromatosis. Gastrin concentrations are increased in the plasma and gastric mucosa of Hfe(-/-) mice, and in the sera of humans with HFE-related hemochromatosis. The discovery of a relationship between iron status and circulating gastrin concentrations opens a new perspective on the mechanisms of iron homeostasis.
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