| First Author | Garcia JA | Year | 2000 |
| Journal | Science | Volume | 288 |
| Issue | 5474 | Pages | 2226-30 |
| PubMed ID | 10864874 | Mgi Jnum | J:63035 |
| Mgi Id | MGI:1860355 | Doi | 10.1126/science.288.5474.2226 |
| Citation | Garcia JA, et al. (2000) Impaired cued and contextual memory in NPAS2-deficient mice. Science 288(5474):2226-30 |
| abstractText | Neuronal PAS domain protein 2 (NPAS2) is a basic helix-loop-helix (bHLH) PAS domain transcription factor expressed in multiple regions of the vertebrate brain. Targeted insertion of a beta-galactosidase reporter gene (lacZ) resulted in the production of an NPAS2-lacZ fusion protein and an altered form of NPAS2 lacking the bHLH domain. The neuroanatomical expression pattern of NPAS2-lacZ was temporally and spatially coincident with formation of the mature frontal association/limbic forebrain pathway. NPAS2-deficient mice were subjected to a series of behavioral tests and were found to exhibit deficits in the long-term memory arm of the cued and contextual fear task. Thus, NPAS2 may serve a dedicated regulatory role in the acquisition of specific types of memory. |
