| First Author | Friedman RS | Year | 2006 |
| Journal | Nat Immunol | Volume | 7 |
| Issue | 10 | Pages | 1101-8 |
| PubMed ID | 16964261 | Mgi Jnum | J:112630 |
| Mgi Id | MGI:3662949 | Doi | 10.1038/ni1384 |
| Citation | Friedman RS, et al. (2006) Surface-bound chemokines capture and prime T cells for synapse formation. Nat Immunol 7(10):1101-8 |
| abstractText | T cell activation in vivo occurs in a lymphoid milieu that presents chemotactic and T cell receptor signals concurrently. Here we demonstrate that T cell zone chemokines such as CCL21 are bound to the surface of lymph node dendritic cells. Contact with antigen-presenting cells bearing chemokines costimulated T cells by a previously unknown two-step contact mechanism. T cells initially formed an antigen-independent 'tethered' adhesion on chemokine-bearing antigen-presenting cells. The formation of those tethers superseded T cell receptor signaling and immunological synapse formation. However, chemokine-tethered T cells were hyper-responsive to subsequent contacts with antigen-presenting cells. Thus, T cells are costimulated 'in trans' and sequentially after initial engagement with their chemokine-rich environment. |
