| First Author | Fernandes VE | Year | 2020 |
| Journal | PLoS Pathog | Volume | 16 |
| Issue | 4 | Pages | e1008464 |
| PubMed ID | 32324805 | Mgi Jnum | J:293426 |
| Mgi Id | MGI:6452669 | Doi | 10.1371/journal.ppat.1008464 |
| Citation | Fernandes VE, et al. (2020) The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection. PLoS Pathog 16(4):e1008464 |
| abstractText | Streptococcus pneumoniae is a major human pathogen, causing pneumonia and sepsis. Genetic components strongly influence host responses to pneumococcal infections, but the responsible loci are unknown. We have previously identified a locus on mouse chromosome 7 from a susceptible mouse strain, CBA/Ca, to be crucial for pneumococcal infection. Here we identify a responsible gene, Cd22, which carries a point mutation in the CBA/Ca strain, leading to loss of CD22 on B cells. CBA/Ca mice and gene-targeted CD22-deficient mice on a C57BL/6 background are both similarly susceptible to pneumococcal infection, as shown by bacterial replication in the lungs, high bacteremia and early death. After bacterial infections, CD22-deficient mice had strongly reduced B cell populations in the lung, including GM-CSF producing, IgM secreting innate response activator B cells, which are crucial for protection. This study provides striking evidence that CD22 is crucial for protection during invasive pneumococcal disease. |
