| First Author | O'Keefe TL | Year | 1996 |
| Journal | Science | Volume | 274 |
| Issue | 5288 | Pages | 798-801 |
| PubMed ID | 8864124 | Mgi Jnum | J:76974 |
| Mgi Id | MGI:2180693 | Doi | 10.1126/science.274.5288.798 |
| Citation | O'Keefe TL, et al. (1996) Hyperresponsive B cells in CD22-deficient mice. Science 274(5288):798-801 |
| abstractText | CD22 is a surface glycoprotein of B lymphocytes that is rapidly phosphorylated on cytoplasmic tyrosines after antigen receptor cross-linking. Splenic B cells from mice with a disrupted CD22 gene were found to be hyperresponsive to receptor signaling: Heightened calcium fluxes and cell proliferation were obtained at lower ligand concentrations. The mice gave an augmented immune response, had an expanded peritoneal B-1 cell population, and contained increased serum titers of autoantibody. Thus, CD22 is a negative regulator of antigen receptor signaling whose onset of expression at the mature B cell stage may serve to raise the antigen concentration threshold required for B cell triggering. |
