| First Author | Duitman J | Year | 2012 |
| Journal | Proc Natl Acad Sci U S A | Volume | 109 |
| Issue | 23 | Pages | 9113-8 |
| PubMed ID | 22615380 | Mgi Jnum | J:184744 |
| Mgi Id | MGI:5426275 | Doi | 10.1073/pnas.1202641109 |
| Citation | Duitman J, et al. (2012) CCAAT/enhancer-binding protein delta facilitates bacterial dissemination during pneumococcal pneumonia in a platelet-activating factor receptor-dependent manner. Proc Natl Acad Sci U S A 109(23):9113-8 |
| abstractText | CCAAT/enhancer-binding protein delta (C/EBPdelta) recently emerged as an essential player in the inflammatory response to bacterial infections. C/EBPdelta levels increase rapidly after a proinflammatory stimulus, and increasing C/EBPdelta levels seem to be indispensable for amplification of the inflammatory response. Here we aimed to elucidate the role of C/EBPdelta in host defense in community-acquired pneumococcal pneumonia. We show that C/EBPdelta(-/-) mice are relatively resistant to pneumococcal pneumonia, as indicated by delayed and reduced mortality, diminished outgrowth of pneumococci in lungs, and reduced dissemination of the infection. Moreover, expression of platelet-activating factor receptor (PAFR), which is known to potentiate bacterial translocation of Gram-positive bacteria, was significantly reduced during infection in C/EBPdelta(-/-) mice compared with WT controls. Importantly, cell stimulation experiments revealed that C/EBPdelta potentiates PAFR expression induced by lipoteichoic acid and pneumococci. Thus, C/EBPdelta exaggerates bacterial dissemination during Streptococcus pneumoniae-induced pulmonary infection, suggesting an important role for PAFR-dependent bacterial translocation. |
