| First Author | Bang YJ | Year | 2021 |
| Journal | Science | Volume | 373 |
| Issue | 6561 | Pages | eabf9232 |
| PubMed ID | 34529485 | Mgi Jnum | J:311719 |
| Mgi Id | MGI:6771438 | Doi | 10.1126/science.abf9232 |
| Citation | Bang YJ, et al. (2021) Serum amyloid A delivers retinol to intestinal myeloid cells to promote adaptive immunity. Science 373(6561):eabf9232 |
| abstractText | Vitamin A and its derivative retinol are essential for the development of intestinal adaptive immunity. Retinoic acid (RA)âproducing myeloid cells are central to this process, but how myeloid cells acquire retinol for conversion to RA is unknown. Here, we show that serum amyloid A (SAA) proteinsâretinol-binding proteins induced in intestinal epithelial cells by the microbiotaâdeliver retinol to myeloid cells. We identify low-density lipoprotein (LDL) receptorârelated protein 1 (LRP1) as an SAA receptor that endocytoses SAA-retinol complexes and promotes retinol acquisition by RA-producing intestinal myeloid cells. Consequently, SAA and LRP1 are essential for vitamin Aâdependent immunity, including B and T cell homing to the intestine and immunoglobulin A production. Our findings identify a key mechanism by which vitamin A promotes intestinal immunity. |
