| First Author | Hirota K | Year | 2013 |
| Journal | Nat Immunol | Volume | 14 |
| Issue | 4 | Pages | 372-9 |
| PubMed ID | 23475182 | Mgi Jnum | J:194909 |
| Mgi Id | MGI:5475048 | Doi | 10.1038/ni.2552 |
| Citation | Hirota K, et al. (2013) Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses. Nat Immunol 14(4):372-9 |
| abstractText | Intestinal Peyer's patches are essential lymphoid organs for the generation of T cell-dependent immunoglobulin A (IgA) for gut homeostasis. Through the use of interleukin 17 (IL-17) fate-reporter mice, we found here that endogenous cells of the TH17 subset of helper T cells in lymphoid organs of naive mice 'preferentially' homed to the intestines and were maintained independently of IL-23. In Peyer's patches, such TH17 cells acquired a follicular helper T cell (TFH cell) phenotype and induced the development of IgA-producing germinal center B cells. Mice deficient in TH17 cells failed to generate antigen-specific IgA responses, which provides evidence that TH17 cells are the crucial subset required for the production of high-affinity T cell-dependent IgA. |
