| First Author | Elliott JI | Year | 1996 |
| Journal | Eur J Immunol | Volume | 26 |
| Issue | 4 | Pages | 953-6 |
| PubMed ID | 8625995 | Mgi Jnum | J:32586 |
| Mgi Id | MGI:80080 | Doi | 10.1002/eji.1830260436 |
| Citation | Elliott JI, et al. (1996) Non-obese diabetic mice hemizygous at the T cell receptor alpha locus are susceptible to diabetes and sialitis. Eur J Immunol 26(4):953-956 |
| abstractText | To test the hypothesis that T cells carrying two T cell receptor (TCR)alpha chains play a role in autoimmunity, we backcrossed the non-obese diabetic (NOD) strain with one carrying a TCR alpha gene disrupted by homologous recombination. Mice carrying one copy of the disrupted gene are incapable of generating T cells carrying two cell surface TCR alpha chains. Our early results suggested that either dual TCR alpha T cells play a role in insulin- dependent diabetes mellitus (IDDM) induction in NOD mice or that a locus co-segregating with the disrupted TCR alpha locus protected mice from diabetes induction. From the analysis both of mice in which the region co- segregating with the disrupted TCR alpha locus is minimized and of the F-1 offspring of NOD mice with the 129 strain (TCR alpha hemizygous mice), the apparent protective effect of the absence of dual TCR alpha T cells is lost; thus, such cells do not appear to play a critical role in autoimmune disease in NOD mice. |
