| First Author | Culemann S | Year | 2023 |
| Journal | J Exp Med | Volume | 220 |
| Issue | 6 | PubMed ID | 36976180 |
| Mgi Jnum | J:349821 | Mgi Id | MGI:7538809 |
| Doi | 10.1084/jem.20220525 | Citation | Culemann S, et al. (2023) Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes. J Exp Med 220(6) |
| abstractText | Clodronate liposomes (Clo-Lip) have been widely used to deplete mononuclear phagocytes (MoPh) to study the function of these cells in vivo. Here, we revisited the effects of Clo-Lip together with genetic models of MoPh deficiency, revealing that Clo-Lip exert their anti-inflammatory effects independent of MoPh. Notably, not only MoPh but also polymorphonuclear neutrophils (PMN) ingested Clo-Lip in vivo, which resulted in their functional arrest. Adoptive transfer of PMN, but not of MoPh, reversed the anti-inflammatory effects of Clo-Lip treatment, indicating that stunning of PMN rather than depletion of MoPh accounts for the anti-inflammatory effects of Clo-Lip in vivo. Our data highlight the need for a critical revision of the current literature on the role of MoPh in inflammation. |
