| First Author | Raimondi G | Year | 2006 |
| Journal | J Immunol | Volume | 176 |
| Issue | 7 | Pages | 4021-8 |
| PubMed ID | 16547237 | Mgi Jnum | J:129896 |
| Mgi Id | MGI:3770360 | Doi | 10.4049/jimmunol.176.7.4021 |
| Citation | Raimondi G, et al. (2006) Induction of peripheral T cell tolerance by antigen-presenting B cells. II. Chronic antigen presentation overrules antigen-presenting B cell activation. J Immunol 176(7):4021-8 |
| abstractText | Ag presentation in the absence of danger signals and Ag persistence are the inductive processes of peripheral T cell tolerization proposed so far. Nevertheless, it has never been definitively shown that chronic Ag presentation per se can induce T cell tolerance independent of the state of activation of APCs. In the present work, we investigated whether chronic Ag presentation by either resting or activated B cells can induce tolerance of peripheral Ag-specific T cells. We show that CD4(+) T cells that re-encounter the Ag for a prolonged period, presented either by resting or activated Ag-presenting B cells, become nonfunctional and lose any autoimmune reactivity. Thus, when the main APCs are B cells, the major mechanism responsible for peripheral T cell tolerization is persistent Ag exposure, independent of the B cell activation state. |
