| First Author | Saika S | Year | 2000 |
| Journal | J Biol Chem | Volume | 275 |
| Issue | 4 | Pages | 2607-12 |
| PubMed ID | 10644720 | Mgi Jnum | J:60203 |
| Mgi Id | MGI:1352968 | Doi | 10.1074/jbc.275.4.2607 |
| Citation | Saika S, et al. (2000) Role of lumican in the corneal epithelium during wound healing. J Biol Chem 275(4):2607-12 |
| abstractText | Lumican regulates collagenous matrix assembly as a keratan sulfate proteoglycan in the cornea and is also present in the connective tissues of other organs and embryonic corneal stroma as a glycoprotein. In normal unwounded cornea, lumican is expressed by stromal keratocytes. Our data show that injured mouse corneal epithelium ectopically and transiently expresses lumican during the early phase of wound healing, suggesting a potential lumican functionality unrelated to regulation of collagen fibrillogenesis, e. g. modulation of epithelial cell adhesion or migration. An anti-lumican antibody was found to retard corneal epithelial wound healing in cultured mouse eyes. Healing of a corneal epithelial injury in Lum(-/-) mice was significantly delayed compared with Lum(+/-) mice. These observations indicate that lumican expressed in injured epithelium may modulate cell behavior such as adhesion or migration, thus contributing to corneal epithelial wound healing. |
