| First Author | Matsumoto G | Year | 2000 |
| Journal | Eur J Immunol | Volume | 30 |
| Issue | 12 | Pages | 3723-31 |
| PubMed ID | 11169416 | Mgi Jnum | J:71766 |
| Mgi Id | MGI:2150782 | Doi | 10.1002/1521-4141(200012)30:12<3723::AID-IMMU3723>3.0.CO;2-9 |
| Citation | Matsumoto G, et al. (2000) Adhesion mediated by LFA-1 is required for efficient IL-12-induced NK and NKT cell cytotoxicity. Eur J Immunol 30(12):3723-31 |
| abstractText | Interleukin 12 (IL-12)-activated NK1.1+TCRalpha beta+ (NKT2) and NK1.1+TCRalpha beta- (NK) cells exhibit cytotoxic activity against a wide variety of tumor cells in the absence of prior sensitization. Here we demonstrate that the integrin adhesion receptor LFA-1 (CD11a/CD18) regulates the cytotoxic activity of IL-12-activated NKT and NK cells against YAC-1 and EL-4 tumor cells. Differentiation in vivo and the expression of the cytolytic effector molecules perforin and Fas-L were comparable in both IL-12-activated NKT and NK cells from LFA-1-/ - and LFA-1+/+ mice. However, LFA-1-/-IL-12-activated NKT and NK cells showed impaired conjugate formation with target cells. These results provide the first genetic evidence for a role for an adhesion receptor in killing by IL-12-activated NK cells. |
