| First Author | Wang Y | Year | 2007 |
| Journal | Biochem Biophys Res Commun | Volume | 353 |
| Issue | 4 | Pages | 857-62 |
| PubMed ID | 17207459 | Mgi Jnum | J:117845 |
| Mgi Id | MGI:3697797 | Doi | 10.1016/j.bbrc.2006.12.104 |
| Citation | Wang Y, et al. (2007) A critical role of LFA-1 in the development of Th17 cells and induction of experimental autoimmune encephalomyelytis. Biochem Biophys Res Commun 353(4):857-62 |
| abstractText | The alphaLbeta2 integrin adhesion molecule LFA-1 is believed to be involved in the migration of autoreactive T cells to the central nervous system across the endothelial blood-brain barrier in experimental autoimmune encephalomyelitis (EAE). Here, we demonstrate that the incidence and clinical scores of EAE in LFA-1(-/-) mice induced by the immunization with the myelin oligodendrocyte glycoprotein (MOG)-peptide antigen were significantly lower than those in wild type mice. Further studies demonstrated that lymphocytes recruitment to the draining lymph nodes (dLN) after the immunization with the MOG-peptide was severely suppressed in LFA-1(-/-) mice. Moreover, generation of the MOG-specific IL-17-producing helper T (Th17) cells in the dLN was impaired in LFA-1(-/-) mice. These results suggest that LFA-1 may play an important role for the generation of MOG-specific Th17 cells in the dLN as well as the immigration of MOG-specific naive CD4(+) T cells to the dLN. |
