| First Author | Matsumoto G | Year | 2004 |
| Journal | J Immunol | Volume | 173 |
| Issue | 8 | Pages | 4976-84 |
| PubMed ID | 15470040 | Mgi Jnum | J:93710 |
| Mgi Id | MGI:3505606 | Doi | 10.4049/jimmunol.173.8.4976 |
| Citation | Matsumoto G, et al. (2004) Essential role of LFA-1 in activating Th2-like responses by alpha-galactosylceramide-activated NKT cells. J Immunol 173(8):4976-84 |
| abstractText | NKT cells produce large amounts of cytokines associated with both the Th1 (IFN-gamma) and Th2 (IL-4) responses following stimulation of their invariant Valpha14 Ag receptor. The role of adhesion molecules in the activation of NKT cells by the Valpha14 ligand alpha-galactosylceramide (alpha-GalCer) remains unclear. To address this issue, LFA-1-/- (CD11a-/-) mice were used to investigate IL-4 and IFN-gamma production by NKT cells following alpha-GalCer stimulation. Intriguingly, LFA-1-/- mice showed increased IL-4, IL-5, and IL-13 production and polarized Th2-type responses in response to alpha-GalCer in vitro and in vivo. Furthermore, the Th2-specific transcription factor GATA-3 was up-regulated in alpha-GalCer-activated NKT cells from LFA-1-/- mice. These results provide the first genetic evidence that the adhesion receptor LFA-1 has a crucial role in Th2-polarizing functions of NKT cells. |
