| First Author | Zhang J | Year | 2019 |
| Journal | J Cereb Blood Flow Metab | Volume | 39 |
| Issue | 9 | Pages | 1836-1848 |
| PubMed ID | 29658368 | Mgi Jnum | J:321847 |
| Mgi Id | MGI:6869760 | Doi | 10.1177/0271678X18769770 |
| Citation | Zhang J, et al. (2019) The AAA + ATPase Thorase is neuroprotective against ischemic injury. J Cereb Blood Flow Metab 39(9):1836-1848 |
| abstractText | Neuronal preconditioning in vitro or in vivo with a stressful but non-lethal stimulus leads to new protein expression that mediates a profound neuroprotection against glutamate excitotoxicity and experimental stroke. The proteins that mediate neuroprotection are relatively unknown and under discovery. Here we find that the expression of the AAA + ATPase Thorase is induced by preconditioning stimulation both in vitro and in vivo. Thorase provides neuroprotection in an ATP-dependent manner against oxygen-glucose deprivation (OGD) neurotoxicity or glutamate N-Methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity in vitro. Knock-down of Thorase prevents the establishment of preconditioning induced neuroprotection against OGD or NMDA neurotoxicity. Transgenic overexpression of Thorase provides neuroprotection in vivo against middle cerebral artery occlusion (MCAO)-induced stroke in mice, while genetic deletion of Thorase results in increased injury in vivo following stroke. These results define Thorase as a neuroprotective protein and understanding Thorase signaling could offer a new therapeutic strategy for the treatment of neurologic disorders. |
