| First Author | Zhou M | Year | 2010 |
| Journal | Neurobiol Learn Mem | Volume | 94 |
| Issue | 4 | Pages | 530-7 |
| PubMed ID | 20849967 | Mgi Jnum | J:166084 |
| Mgi Id | MGI:4839689 | Doi | 10.1016/j.nlm.2010.09.005 |
| Citation | Zhou M, et al. (2010) Both mineralocorticoid and glucocorticoid receptors regulate emotional memory in mice. Neurobiol Learn Mem 94(4):530-7 |
| abstractText | Corticosteroid hormones are thought to promote optimal behavioral adaptation under fearful conditions, primarily via glucocorticoid receptors (GRs). Here, we examined - using pharmacological and genetic approaches in mice - if mineralocorticoid receptors (MRs) also play a role in fearful memory formation. As expected, administration of the GR-antagonist RU38486 prior to training in a fear conditioning paradigm impaired contextual memory when tested 24 (but not when tested 3) h after training. Tone-cue memory was enhanced by RU38486 when tested at 4 (but not 25) h after training. Interestingly, pre (but not post)-training administration of MR antagonist spironolactone impaired contextual memory, both at 3 and 24h after training. Similar effects were also found in forebrain-specific MR knockout mice. Spironolactone also impaired tone-cue memory, but only at 4h after training. These results reveal that - in addition to GRs - MRs also play a critical role in establishing fear memories, particularly in the early phase of memory formation. |
