| First Author | Salvioni A | Year | 2019 |
| Journal | Cell Rep | Volume | 27 |
| Issue | 11 | Pages | 3254-3268.e8 |
| PubMed ID | 31189109 | Mgi Jnum | J:284394 |
| Mgi Id | MGI:6381026 | Doi | 10.1016/j.celrep.2019.05.051 |
| Citation | Salvioni A, et al. (2019) Robust Control of a Brain-Persisting Parasite through MHC I Presentation by Infected Neurons. Cell Rep 27(11):3254-3268.e8 |
| abstractText | Control of CNS pathogens by CD8 T cells is key to avoid fatal neuroinflammation. Yet, the modalities of MHC I presentation in the brain are poorly understood. Here, we analyze the antigen presentation mechanisms underlying CD8 T cell-mediated control of the Toxoplasma gondii parasite in the CNS. We show that MHC I presentation of an efficiently processed model antigen (GRA6-OVA), even when not expressed in the bradyzoite stage, reduces cyst burden and dampens encephalitis in C57BL/6 mice. Antigen presentation assays with infected primary neurons reveal a correlation between lower MHC I presentation of tachyzoite antigens by neurons and poor parasite control in vivo. Using conditional MHC I-deficient mice, we find that neuronal MHC I presentation is required for robust restriction of T. gondii in the CNS during chronic phase, showing the importance of MHC I presentation by CNS neurons in the control of a prevalent brain pathogen. |
