Primary Identifier | MGI:2181543 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Phlda2 |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Homologous recombination introduced loxP sites flanking the 2 exons of the gene. Mice carrying the targeted mutation were bred to the HSP-cre deleter strain resulting in deletion of the 2 exons and of half of the 5' upstream CpG islands. Absence of gene expression in yolk sacs of homozygous mutant embryos was demonstrated by Northern blot analysis. |