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Allele : Tg(RHO-P23H)DTpd transgene insertion D, Thaddeus P Dryja
Primary Identifier  MGI:2181671 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(RHO-P23H)DTpd
Strain of Origin  (C57BL/6 x DBA/2)F1 Is Recombinase  false
Is Wild Type  false
description  Mutant lines D, E, and L harboring the mutant human rhodopsin gene were constructed. Lines D and E express 3x and 1x the amount of endogenous rhodopsin, respectively, resulting in severe retinitis pigmentosa. Line L expresses 1/6x the amount of endogenous rhodopsin and exhibits a mild disease phenotype.
molecularNote  The entire coding region of mutant human rhodopsin (P23H) implicated in dominantly inherited retinitis pigmentosa was used for the transgene. The transgene includes 4.2 kb of upstream sequence and 8.4 kb of downstream sequence.
  • mutations:
  • Insertion
  • synonyms:
  • P23H-D,
  • P23H-D
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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