| Primary Identifier | MGI:2182147 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(MSV-Nfl)58Dwc |
| Strain of Origin | (C57BL/6 x A/J)F1 | Is Recombinase | false |
| Is Wild Type | false |
| description | Founder NF-L58 is representative of 2 high expressing transgenic lines. Cataracts were observed in transgenic animals (see reference J:76721). Doubly transgenic animals created by mating of the 2 high expressing founders exhibit low body weight and severe muscular atrophy by 21 days of age (see reference J:42835). |
| molecularNote | The entire mouse Nfl gene, including 1.7 kb of sequences upstream of the translation initiation codon and 1.7 kb of 3' terminal noncoding sequences, was used for the transgene. The murine sarcoma virus (MSV) LTR was used to drive strong expression of thetransgene. |
