| First Author | Cariappa A | Year | 2005 |
| Journal | J Immunol | Volume | 175 |
| Issue | 5 | Pages | 2925-30 |
| PubMed ID | 16116178 | Mgi Jnum | J:113252 |
| Mgi Id | MGI:3664851 | Doi | 10.4049/jimmunol.175.5.2925 |
| Citation | Cariappa A, et al. (2005) The CD9 tetraspanin is not required for the development of peripheral B cells or for humoral immunity. J Immunol 175(5):2925-30 |
| abstractText | The CD9 tetraspanin is known to be expressed at high levels on marginal zone (MZ) B cells, B-1 B cells, and plasma cells, and its expression is believed to be dependent on signals derived via Btk. In CD9 null mice, however, the development and survival of MZ B cells, B-1 B cells, and plasma cells all appear to be unaffected, and humoral immune responses to T-dependent and T-independent Ags are similar to those seen in wild-type littermate controls. In wild-type mice, CD9 levels may serve to distinguish between the presumed MZ precursor B cell population in the spleen and other IgD-expressing transitional B cells that express lower levels of CD21 and CD1d. These results suggest that CD9 is dispensable for B cell development and humoral immunity, but that this protein may serve as an additional marker for the presumed MZ precursor population of splenic B cells. |
