| First Author | Socolovsky M | Year | 1999 |
| Journal | Cell | Volume | 98 |
| Issue | 2 | Pages | 181-91 |
| PubMed ID | 10428030 | Mgi Jnum | J:56510 |
| Mgi Id | MGI:1341482 | Doi | 10.1016/s0092-8674(00)81013-2 |
| Citation | Socolovsky M, et al. (1999) Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction. Cell 98(2):181-91 |
| abstractText | The erythropoietin receptor (EpoR) is essential for production of red blood cells; a principal function of EpoR is to rescue committed erythroid progenitors from apoptosis. Stat5 is rapidly activated following EpoR stimulation, but its function in erythropoiesis has been unclear since adult Stat5a-/-5b-/- mice have normal steady-state hematocrit. Here we show that Stat5 is essential for the high erythropoietic rate during fetal development. Stat5a-/-5b-/- embryos are severely anemic; erythroid progenitors are present in low numbers, show higher levels of apoptosis, and are less responsive to Epo. These findings are explained by a crucial role for Stat5 in EpoR's antiapoptotic signaling: it mediates the immediate-early induction of Bcl-X(L) in erythroid cells through direct binding to the Bcl-X promoter. |
