| First Author | Fain JN | Year | 1999 |
| Journal | Biochem Biophys Res Commun | Volume | 263 |
| Issue | 1 | Pages | 201-5 |
| PubMed ID | 10486277 | Mgi Jnum | J:57705 |
| Mgi Id | MGI:1345565 | Doi | 10.1006/bbrc.1999.1302 |
| Citation | Fain JN, et al. (1999) Stimulation of lipolysis but not of leptin release by growth hormone is abolished in adipose tissue from Stat5a and b knockout mice. Biochem Biophys Res Commun 263(1):201-5 |
| abstractText | The present studies examined the effects of growth hormone (GH) on lipolysis and leptin release by adipose tissue from mice incubated for 24 h in primary culture. In adipose tissue from control mice GH enhanced lipolysis without affecting leptin release. The lipolytic action of GH was unaffected in adipose tissue from Stat5b-/- male mice but leptin release was enhanced by GH in fat from Stat5b-/- mice. In adipose tissue from Stat5ab-/- female mice no significant lipolytic action of GH was seen but leptin release was enhanced by GH. An insulin-like effect of GH on glucose conversion to lactate was also seen in mice deficient in Stat5ab-/-. These results suggest that the lipolytic action of GH involves the Stat5 proteins while the insulin-like effects of GH on glucose metabolism and leptin release involve different mechanisms. Copyright 1999 Academic Press. |
