| First Author | Turner KN | Year | 2009 |
| Journal | Dev Dyn | Volume | 238 |
| Issue | 3 | Pages | 708-15 |
| PubMed ID | 19235728 | Mgi Jnum | J:146221 |
| Mgi Id | MGI:3837059 | Doi | 10.1002/dvdy.21861 |
| Citation | Turner KN, et al. (2009) Cell adhesion molecule L1 affects the rate of differentiation of enteric neurons in the developing gut. Dev Dyn 238(3):708-15 |
| abstractText | The enteric nervous system arises predominantly from vagal level neural crest cells that migrate into and along the developing gut. As the neural crest-derived cells migrate within the gut, a subpopulation begins to differentiate into enteric neurons. Here, we show that the differentiation of neural crest-derived cells into enteric neurons is delayed in L1-deficient mice, compared with littermate controls. However, glial cell differentiation is not affected in L1-deficient mice. These mice also show a delay in the differentiation of a neurotransmitter-specific subtype of enteric neuron within the gastrointestinal tract. Together, these results suggest a role for the cell adhesion molecule, L1, in the differentiation of neural crest-derived cells into enteric neurons within the developing enteric nervous system. Developmental Dynamics 238:708-715, 2009. (c) 2009 Wiley-Liss, Inc. |
