| First Author | Grootegoed JA | Year | 1998 |
| Journal | Mol Cell Endocrinol | Volume | 145 |
| Issue | 1-2 | Pages | 161-6 |
| PubMed ID | 9922113 | Mgi Jnum | J:52347 |
| Mgi Id | MGI:1328888 | Doi | 10.1016/s0303-7207(98)00183-x |
| Citation | Grootegoed JA, et al. (1998) Knockout mouse model and gametogenic failure. Mol Cell Endocrinol 145(1-2):161-6 |
| abstractText | To evaluate the function of a defined gene in gametogenesis, exciting opportunities are offered by the introduction of techniques to generate knockout mice. In this short article, we briefly describe a few gene knockout mouse models, which show a phenotype that involves impairment of gametogenesis and/or fertility. The focus will be on the mHR6B gene knockout mouse, which shows male infertility. The mHR6B gene encodes an ubiquitin-conjugating enzyme, and the data point to an important role of the ubiquitin pathway in gametogenesis. |
