| First Author | Harasawa I | Year | 2003 |
| Journal | Neuroreport | Volume | 14 |
| Issue | 14 | Pages | 1857-60 |
| PubMed ID | 14534435 | Mgi Jnum | J:89709 |
| Mgi Id | MGI:3041311 | Doi | 10.1097/00001756-200310060-00020 |
| Citation | Harasawa I, et al. (2003) Responses to noxious stimuli in mice lacking alpha(1d)-adrenergic receptors. Neuroreport 14(14):1857-60 |
| abstractText | Nociceptive behaviors were examined in the mice lacking alpha1d-adrenergic receptor (alpha1d-AR) and wild type littermates using tail-flick, hot-plate (hindpaw-licking and jumping), tail-pinch and formalin tests. The distribution of alpha1d-AR was studied using in situ hybridization in the wild type mice. Mutant mice showed longer tail-flick and hindpaw-licking latencies while their jumping latency was shorter. Mechanical and chemical nociception was not altered in alpha1d-knockout mice. In situ hybridization study revealed dense alpha1d-AR mRNA expression in the reticular thalamic nucleus, the hippocampus, the cingulate cortex and the spinal cord. These results suggest that alpha1d-AR in the spinal cord contributes to thermal pronociception; and that the jump behavior seen when escaping from heat is inhibited via the supraspinal alpha1d-AR. |
