| First Author | Wang Y | Year | 2008 |
| Journal | Biochem Biophys Res Commun | Volume | 370 |
| Issue | 2 | Pages | 201-6 |
| PubMed ID | 18343216 | Mgi Jnum | J:134494 |
| Mgi Id | MGI:3788976 | Doi | 10.1016/j.bbrc.2008.03.031 |
| Citation | Wang Y, et al. (2008) BRCA1 regulates caveolin-1 expression and inhibits cell invasiveness. Biochem Biophys Res Commun 370(2):201-6 |
| abstractText | BRCA1 is involved in multiple biological processes including DNA damage repair, cell growth, apoptosis, and transcriptional activation. Also, BRCA1 plays key roles in inhibiting cancer progression. Caveolin-1 is identified as a tumor suppressor and regulates the invasiveness of cells. However, the interactions between BRCA1 and caveolin-1 remain largely unknown. We have investigated the potential function of BRCA1 in regulation of caveolin-1 gene expression and its subcellular localization as well. The observations from RT-PCR, transfection, RNAi, and luciferase assays implied that BRCA1 could elevate caveolin-1 mRNA levels via transactivation of the caveolin-1 promoter region. Additionally, immunofluorescent approach showed that BRCA1 might inhibit the invasiveness and metastatic abilities of mammalian cells by inducing the redistribution of caveolin-1 from the cytoplasm to the cell membrane. |
