| First Author | Ueda H | Year | 1997 |
| Journal | Neurosci Lett | Volume | 237 |
| Issue | 2-3 | Pages | 136-8 |
| PubMed ID | 9453234 | Mgi Jnum | J:45275 |
| Mgi Id | MGI:1194721 | Doi | 10.1016/s0304-3940(97)00832-x |
| Citation | Ueda H, et al. (1997) Partial loss of tolerance liability to morphine analgesia in mice lacking the nociceptin receptor gene. Neurosci Lett 237(2-3):136-8 |
| abstractText | In mice lacking the nociceptin (or orphanin FQ) receptor gene, when 10 mg/kg of morphine was subcutaneously given, a potent analgesia in the tail pinch test was observed. The analgesic effect of morphine was equivalent among wild-type, heterozygous and homozygous mutant mice. When morphine was given to such mice in a dose of 10 mg/kg once per day for 5 days, wild-type and heterozygous mice showed marked tolerance or reduction in the morphine analgesia on the 5th day, while homozygous mice showed only 50% reduction in the peripheral analgesia of morphine. These findings suggest that nociceptin or its receptor plays important roles in the in vivo mechanism for the development of morphine tolerance. |
