| First Author | Fulceri R | Year | 2001 |
| Journal | Biochem Biophys Res Commun | Volume | 288 |
| Issue | 3 | Pages | 697-702 |
| PubMed ID | 11676499 | Mgi Jnum | J:72654 |
| Mgi Id | MGI:2153367 | Doi | 10.1006/bbrc.2001.5834 |
| Citation | Fulceri R, et al. (2001) Ca(2+) release induced by cyclic adp ribose in mice lacking type 3 ryanodine receptor. Biochem Biophys Res Commun 288(3):697-702 |
| abstractText | The action of cyclic-ADP-ribose was studied on calcium release from sarcoplasmic reticulum of skeletal muscles of neonatal and adult wild-type and RyR3-deficient mice. cADPR increased calcium efflux from microsomes, enhanced caffeine-induced calcium release, and, in 20% of the tests, triggered calcium release in single muscle fibers. These responses occurred only in the diaphragm of adult RyR3-deficient mice. cADPR action was abolished by ryanodine, ruthenium red, and 8-brome-cADPR. These results strongly favor a specific action of cADPR on RyR1. The responsiveness of RyR1 appears in adult muscles when RyR3 is lacking. Copyright 2001 Academic Press. |
