| First Author | Garín MI | Year | 2007 |
| Journal | Blood | Volume | 109 |
| Issue | 5 | Pages | 2058-65 |
| PubMed ID | 17110462 | Mgi Jnum | J:145355 |
| Mgi Id | MGI:3834340 | Doi | 10.1182/blood-2006-04-016451 |
| Citation | Garin MI, et al. (2007) Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells. Blood 109(5):2058-65 |
| abstractText | The naturally occurring population of dedicated regulatory T cells that coexpress CD4 and CD25 is known to play a key role in the maintenance of peripheral T-cell tolerance; however, their mechanism of action has remained obscure. Here we report that a member of the family of beta-galactoside-binding proteins, galectin-1, is overexpressed in regulatory T cells, and that expression is increased after activation. Most importantly, blockade of galectin-1 binding significantly reduced the inhibitory effects of human and mouse CD4+CD25+ T cells. Reduced regulatory activity was observed in CD4+CD25+ T cells obtained from galectin-1-homozygous null mutant mice. These results suggest that galectin-1 is a key effector of the regulation mediated by these cells. |
