| First Author | van Woerden GM | Year | 2007 |
| Journal | Nat Neurosci | Volume | 10 |
| Issue | 3 | Pages | 280-2 |
| PubMed ID | 17259980 | Mgi Jnum | J:120721 |
| Mgi Id | MGI:3707896 | Doi | 10.1038/nn1845 |
| Citation | van Woerden GM, et al. (2007) Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylation. Nat Neurosci 10(3):280-2 |
| abstractText | Angelman syndrome (AS) is a severe neurological disorder characterized by mental retardation, motor dysfunction and epilepsy. We show that the molecular and cellular deficits of an AS mouse model can be rescued by introducing an additional mutation at the inhibitory phosphorylation site of alphaCaMKII. Moreover, these double mutants no longer show the behavioral deficits seen in AS mice, suggesting that these deficits are the direct result of increased inhibitory phosphorylation of alphaCaMKII. |
