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Publication : Optical intrinsic signal mapping of rod- and cone-mediated visual cortex responses in mice.

First Author  Fan X Year  2008
Journal  Vision Res Volume  48
Issue  13 Pages  1441-8
PubMed ID  18495199 Mgi Jnum  J:139774
Mgi Id  MGI:3810037 Doi  10.1016/j.visres.2008.04.012
Citation  Fan X, et al. (2008) Optical intrinsic signal mapping of rod- and cone-mediated visual cortex responses in mice. Vision Res 48(13):1441-8
abstractText  We used optical imaging of intrinsic signals to study visual cortex responses in three mouse strains: wild-type (C57BL/6J), a strain with only rod function (cpfl1), and a strain with only cone function (rho(-/-)). A stationary flicker light stimulus with intensity ranging from 10(8.6) to 10(15.5) photons/cm2/s was used. We found that the intrinsic signal patterns exhibited stimulus intensity-dependent changes. At a given stimulus intensity, the patterns of intrinsic signals were clearly different in the three strains. These results suggest that the lack of normal functions of certain photoreceptors induces significant reorganization in the visual neural systems in mice.
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