| First Author | Fleischmann A | Year | 2000 |
| Journal | Genes Dev | Volume | 14 |
| Issue | 21 | Pages | 2695-700 |
| PubMed ID | 11069886 | Mgi Jnum | J:65766 |
| Mgi Id | MGI:1927277 | Doi | 10.1101/gad.187900 |
| Citation | Fleischmann A, et al. (2000) Fra-1 replaces c-fos-dependent functions in mice. Genes Dev 14(21):2695-700 |
| abstractText | Structure-function analysis as well as studies with knock-out and transgenic mice have assigned distinct functions to c-Fos and Fra-1, two components of the transcription factor AP-1 (activator protein-1). To test whether Fra-1 could substitute for c-Fos, we generated knock-in mice that express Fra-1 in place of c-Fos. Fra-1 rescues c-Fos-dependent functions such as bone development and light-induced photoreceptor apoptosis. Importantly, rescue of bone cell differentiation, but not photoreceptor apoptosis, is gene-dosage dependent. Moreover, Fra-1 fails to substitute for c-Fos in inducing expression of target genes in fibroblasts. These results show that c-Fos and Fra-1 have maintained functional equivalence during vertebrate evolution. |
