| First Author | Lee YN | Year | 2004 |
| Journal | J Immunol | Volume | 173 |
| Issue | 4 | Pages | 2571-7 |
| PubMed ID | 15294973 | Mgi Jnum | J:92652 |
| Mgi Id | MGI:3054266 | Doi | 10.4049/jimmunol.173.4.2571 |
| Citation | Lee YN, et al. (2004) c-Fos as a regulator of degranulation and cytokine production in FcepsilonRI-activated mast cells. J Immunol 173(4):2571-7 |
| abstractText | The AP-1 complex is composed of c-Jun and c-Fos and is a key component in the regulation of proinflammatory genes. Mast cells play a significant role in the initiation of many inflammatory responses, such as allergy and allergy-associated diseases. In the present work, we characterized the role of c-Fos in mast cell function by investigating IL-3-dependent cell proliferation, degranulation capability, and cytokine expression in c-Fos-deficient mice. In c-Fos-deficient mast cells, we found that FcepsilonRI-mediated degranulation was significantly inhibited, which correlates with the reduced expression of SWAP-70, VAMP-7, and Synaptotagmin I genes, which are involved directly in the degranulation process. These findings show that c-Fos plays an important role in FcepsilonRI-mediated regulation of mast cell function. |
