| First Author | Grigoriadis AE | Year | 1994 |
| Journal | Science | Volume | 266 |
| Issue | 5184 | Pages | 443-8 |
| PubMed ID | 7939685 | Mgi Jnum | J:21142 |
| Mgi Id | MGI:69182 | Doi | 10.1126/science.7939685 |
| Citation | Grigoriadis AE, et al. (1994) c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science 266(5184):443-8 |
| abstractText | Mice lacking the proto-oncogene c-fos develop the bone disease osteopetrosis. Fos mutant mice were found to have a block in the differentiation of bone-resorbing osteoclasts that was intrinsic to hematopoietic cells. Bone marrow transplantation rescued the osteopetrosis, and ectopic c-fos expression overcame this differentiation block. The lack of Fos also caused a lineage shift between osteoclasts and macrophages that resulted in increased numbers of bone marrow macrophages. These results identify Fos as a key regulator of osteoclast-macrophage lineage determination in vivo and provide insights into the molecular mechanisms underlying metabolic bone diseases. |
