| First Author | Boucher J | Year | 2012 |
| Journal | Nat Commun | Volume | 3 |
| Pages | 902 | PubMed ID | 22692545 |
| Mgi Jnum | J:205635 | Mgi Id | MGI:5545956 |
| Doi | 10.1038/ncomms1905 | Citation | Boucher J, et al. (2012) Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling. Nat Commun 3:902 |
| abstractText | Insulin and insulin-like growth factor 1 (IGF-1) have important roles in adipocyte differentiation, glucose tolerance and insulin sensitivity. Here to assess how these pathways can compensate for each other, we created mice with a double tissue-specific knockout of insulin and IGF-1 receptors to eliminate all insulin/IGF-1 signalling in fat. These FIGIRKO mice had markedly decreased white and brown fat mass and were completely resistant to high fat diet-induced obesity and age- and high fat diet-induced glucose intolerance. Energy expenditure was increased in FIGIRKO mice despite a >85% reduction in brown fat mass. However, FIGIRKO mice were unable to maintain body temperature when placed at 4 degrees C. Brown fat activity was markedly decreased in FIGIRKO mice but was responsive to beta3-receptor stimulation. Thus, insulin/IGF-1 signalling has a crucial role in the control of brown and white fat development, and, when disrupted, leads to defective thermogenesis and a paradoxical increase in basal metabolic rate. |
