| Primary Identifier | MGI:2182109 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(THY1-Prph1)1Jpj |
| Strain of Origin | (C57BL/6 x C3H)F1 | Is Recombinase | false |
| Is Wild Type | false |
| description | Transgenic animals carry 4 copies of the transgene and begin to develop motor dysfunctions after 2 years of age. Protein expression is increased 4-fold in the ventral roots and 2-fold in the dorsal roots of transgenic animals as determined by Western blot analysis. |
| molecularNote | The full mouse Prph1 sequence starting 23 nucleotides upstream from the translation initiation site and ending 2.5 kb downstream of the polyadenylation signal was used for the transgene. Regulatory sequences from human THY1, which include the THY1 promoter and noncoding exons 1 and 2, were used to drive expression of the transgene. |
