| First Author | Heidbreder K | Year | 2022 |
| Journal | Front Immunol | Volume | 13 |
| Pages | 1040775 | PubMed ID | 36741412 |
| Mgi Jnum | J:336262 | Mgi Id | MGI:7433481 |
| Doi | 10.3389/fimmu.2022.1040775 | Citation | Heidbreder K, et al. (2022) Nr4a1-dependent non-classical monocytes are important for macrophage-mediated wound healing in the large intestine. Front Immunol 13:1040775 |
| abstractText | INTRODUCTION: Macrophages play an important role in intestinal wound healing. However, the trajectories from circulating monocytes to gut macrophages are incompletely understood. METHODS: Taking advantage of mice depleted for non-classical monocytes due to deficiency for the transcription factor Nr4a1, we addressed the relevance of non-classical monocytes for large intestinal wound healing using flow cytometry, in vivo wound healing assays and immunofluorescence. RESULTS: We show that wound healing in Nr4a1-deficient mice is substantially delayed and associated with reduced peri-lesional presence of macrophages with a wound healing phenotype. DISCUSSION: Our data suggest that non-classical monocytes are biased towards wound healing macrophages. These insights might help to understand, how targeting monocyte recruitment to the intestine can be used to modulate intestinal macrophage functions. |
