| First Author | Medici D | Year | 2008 |
| Journal | J Cell Biol | Volume | 182 |
| Issue | 3 | Pages | 459-65 |
| PubMed ID | 18678710 | Mgi Jnum | J:139491 |
| Mgi Id | MGI:3808622 | Doi | 10.1083/jcb.200803024 |
| Citation | Medici D, et al. (2008) FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis. J Cell Biol 182(3):459-65 |
| abstractText | Fibroblast growth factor 23 (FGF-23) and Klotho are secretory proteins that regulate mineral-ion metabolism. Fgf-23(-/-) or Klotho(-/-) knockout mice exhibit several pathophysiological processes consistent with premature aging including severe atrophy of tissues. We show that the signal transduction pathways initiated by FGF-23-Klotho prevent tissue atrophy by stimulating proliferation and preventing apoptosis caused by excessive systemic vitamin D. Because serum levels of active vitamin D are greatly increased upon genetic ablation of Fgf-23 or Klotho, we find that these molecules have a dual role in suppression of apoptotic actions of vitamin D through both negative regulation of 1alpha-hydroxylase expression and phosphoinositide-3 kinase-dependent inhibition of caspase activity. These data provide new insights into the physiological roles of FGF-23 and Klotho. |
