| First Author | Muehleisen B | Year | 2012 |
| Journal | Sci Transl Med | Volume | 4 |
| Issue | 135 | Pages | 135ra66 |
| PubMed ID | 22623742 | Mgi Jnum | J:186648 |
| Mgi Id | MGI:5432840 | Doi | 10.1126/scitranslmed.3003759 |
| Citation | Muehleisen B, et al. (2012) PTH/PTHrP and vitamin D control antimicrobial peptide expression and susceptibility to bacterial skin infection. Sci Transl Med 4(135):135ra66 |
| abstractText | The production of antimicrobial peptides is essential for protection against a wide variety of microbial pathogens and plays an important role in the pathogenesis of several diseases. The mechanisms responsible for expression of antimicrobial peptides are incompletely understood, but a role for vitamin D as a transcriptional inducer of the antimicrobial peptide cathelicidin has been proposed. We show that 1,25-dihydroxyvitamin D(3) (1,25-D3) acts together with parathyroid hormone (PTH), or the shared amino-terminal domain of PTH-related peptide (PTHrP), to synergistically increase cathelicidin and immune defense. Administration of PTH to mouse skin decreased susceptibility to skin infection by group A Streptococcus. Mice on dietary vitamin D(3) restriction that responded with an elevation in PTH have an increased risk of infection if they lack 1,25-D3. These results identify PTH/PTHrP as a variable that serves to compensate for inadequate vitamin D during activation of antimicrobial peptide production. |
